Locations
Columbus, OH, USA · Dublin, CA, USA · dublin, oh, usa
industry
Biotechnology
Size
1 - 10 employees
Stage
Other
founded in
2018
Unmet need: There is an unmet need for a single-column, universal platform method to reliably purify tagless recombinant proteins. Affinity tag methods followed by tag removal, although commonly used, are unreliable, complex, lead to productivity losses in research, and are impractical for biopharmaceutical production. Solution: The key capabilities and advantages of the novel technology for protein purification provided by Protein Capture Science are: 1. Provides tagless purified proteins via tag self-cleavage during affinity purification. 2. Gentle cleaving based on small pH change. 3. Reproducible purity and recovery of target. 4. Tunable target-independent cleavage rate. 5. Scalable from laboratory to manufacturing. 6. Simple and inexpensive buffer requirements. 7. Opportunity to merge multi-platform processes into one platform (from R&D to production). Product: The intein-based product is a resin containing proprietary intein-based fragment that allows traceless and tagless self-cleaving.
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